Helminth β-tubulin inhibitor
Helminth β-tubulin polymerization inhibitor
- Parasite loses glucose uptake and starves
- Selective for parasite tubulin over human
- Blocks helminth microtubule assembly
Drugs with this mechanism (1)
- Albendazole — Benzimidazole anthelmintic with tissue penetration for neurocysticercosis and hydatid disease.
Self-check
- Why does parasite tubulin blockade starve the parasite?
It loses glucose uptake. - What selectivity supports antiparasitic tubulin inhibition?
Parasite tubulin over human tubulin.
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