JmjC histone demethylase cofactor
- Supports removal of methyl marks from histones
- Required cofactor for jmjC histone demethylase
Drugs with this mechanism (1)
- Ascorbic acid — Vitamin C; antioxidant and cofactor for collagen and catecholamine synthesis.
Self-check
- Which demethylases mediated vitamin-C-dependent cell reprogramming in the cited study?
Jhdm1a/1b. - Which histone mark did vitamin C demethylate in cultured mouse embryonic fibroblasts?
H3K36me2/3.
All mechanisms · Open JmjC histone demethylase cofactor in the interactive console ↗