Lysyl hydroxylase cofactor
- Enables collagen cross-linking for tensile strength
- Required cofactor for lysyl hydroxylase
- Works alongside prolyl hydroxylation in collagen maturation
Drugs with this mechanism (1)
- Ascorbic acid — Vitamin C; antioxidant and cofactor for collagen and catecholamine synthesis.
Self-check
- What mechanical property does vitamin C-dependent collagen cross-linking provide?
Tensile strength. - Which other hydroxylation process works alongside lysyl hydroxylation in collagen maturation?
Prolyl hydroxylation.
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