Prolyl hydroxylase cofactor
- Hydroxylates collagen proline — the step lost in scurvy
- Required cofactor for prolyl hydroxylase
- Explains poor wound healing, bleeding gums and perifollicular hemorrhage of vitamin C deficiency
Drugs with this mechanism (1)
- Ascorbic acid — Vitamin C; antioxidant and cofactor for collagen and catecholamine synthesis.
Self-check
- Which collagen amino acid is hydroxylated in this pathway?
Proline. - Name two bleeding signs of vitamin C deficiency.
Bleeding gums and perifollicular hemorrhage.
All mechanisms · Open Prolyl hydroxylase cofactor in the interactive console ↗