Dopamine β-hydroxylase cofactor
- Converts dopamine to norepinephrine in sympathetic neurons and adrenal medulla
- Required cofactor for dopamine β-hydroxylase
- Vitamin C keeps the enzyme’s copper center reduced
Drugs with this mechanism (1)
- Ascorbic acid — Vitamin C; antioxidant and cofactor for collagen and catecholamine synthesis.
Self-check
- Which catecholamine is formed from dopamine in this vitamin C-dependent step?
Norepinephrine. - What does vitamin C keep reduced in dopamine β-hydroxylase?
Its copper center.
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