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APEH inhibitor

• Blocks acylpeptide hydrolase
• A secondary mechanism of some antiepileptics

Drugs with this mechanism (3)

• Ertapenem — Once-daily carbapenem lacking Pseudomonas coverage; convenient for outpatient IV.
• Imipenem — Broad-spectrum carbapenem (with cilastatin); reserved for resistant infections.
• Meropenem — Broad-spectrum carbapenem with good CNS penetration; less seizure-prone than imipenem.

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