Adhesion-blocking antibody
Antibody adhesion/trafficking blockade
- Holds two adhesion surfaces apart so a leukocyte cannot cross the vessel wall
- Natalizumab binds the α4 subunit of α4β1 and α4β7 integrins
- The cell is not killed — it is kept out, which is why PML follows loss of CNS immune surveillance
- Holds two adhesion surfaces apart so a leukocyte cannot cross the vessel wall
- Natalizumab binds the α4 subunit of α4β1 and α4β7 integrins
- The cell is not killed — it is kept out, which is why PML follows loss of CNS immune surveillance
Drugs with this mechanism (1)
- Natalizumab — Highly effective in MS; PML risk stratified by JC virus antibody.
All mechanisms · Open Antibody adhesion/trafficking blockade in the interactive console ↗