Anthracycline cardiotoxicity
- Topoisomerase-IIβ poisoning in cardiomyocytes plus iron-catalyzed radicals → cumulative cardiomyopathy
- Cumulative dose is the main determinant (label tabulates incidence from 300 mg/m²); dexrazoxane protects
- Can present years later — baseline and serial LVEF
- Topoisomerase-IIβ poisoning in cardiomyocytes plus iron-catalyzed radicals → cumulative cardiomyopathy
- Cumulative dose is the main determinant (label tabulates incidence from 300 mg/m²); dexrazoxane protects
- Can present years later — baseline and serial LVEF
Drugs with this mechanism (1)
- Doxorubicin — Anthracycline with cumulative, largely irreversible cardiotoxicity.
All mechanisms · Open Anthracycline cardiotoxicity in the interactive console ↗