Alpha-2-delta modulator
Voltage-gated calcium channel alpha-2-delta subunit modulator
- Not “blocker”
- ↓ Ca²⁺ channel trafficking toward synapse → ↓ glutamate release
Drugs with this mechanism (3)
- Gabapentin — Renally cleared alpha-2-delta ligand for neuralgia and seizures; sedation and misuse.
- Phenibut — GABA-B agonist nootropic sold online; tolerance and severe withdrawal.
- Pregabalin — Linear-kinetic alpha-2-delta ligand for neuropathic pain; edema, sedation and misuse.
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