Alpha-2B antagonist
Alpha-2B adrenergic receptor antagonist
- Mild vasodilation
- Little central effect — the action is vascular
Drugs with this mechanism (5)
- Mirtazapine — Sedating, appetite-stimulating noradrenergic/serotonergic agent; weight gain.
- Mitragynine — Main kratom alkaloid; mu-opioid partial agonist.
- Phenoxybenzamine — Irreversible alpha blocker for pheochromocytoma.
- Phentolamine — Reversible alpha blocker for pheochromocytoma and vasopressor extravasation.
- Yohimbine — Alpha-2 antagonist supplement; raises noradrenaline and anxiety.
Self-check
- What vascular effect follows alpha-2B blockade?
Mild vasodilation. - How substantial is the central effect of alpha-2B blockade?
Little; the action is vascular.
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