Aldosterone synthase inhibitor
- ↓ aldosterone production at its source (CYP11B2)
- ↓ sodium retention and ↑ potassium retention → blood-pressure lowering in resistant hypertension
- Hyperkalemia is the principal mechanism-linked risk
- Selectivity over CYP11B1 spares cortisol
Drugs with this mechanism (1)
- Baxdrostat — First-in-class aldosterone synthase inhibitor for resistant hypertension.
Self-check
- What is the principal mechanism-linked risk of aldosterone synthase inhibition?
Hyperkalemia. - Why is selectivity over CYP11B1 useful?
It spares cortisol.
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