5-HT3 agonist
5-HT3 serotonin receptor agonist
- The only ionotropic (ligand-gated cation channel) serotonin receptor
- Nausea and vomiting via vagal afferents and the chemoreceptor trigger zone
- Increased gut motility and visceral sensation
- 5-HT3 activation by SRIs may be a key mediator of bipolar destabilization (El-Mallakh and Aydin, 2024)
Drugs with this mechanism (1)
- Serotonin — The endogenous ligand at fourteen receptor subtypes; the home of serotonicity — synaptic serotonin elevation.
Self-check
- What distinguishes the 5-HT3 receptor from other serotonin receptors?
It is an ionotropic, ligand-gated cation channel. - Through which peripheral nerve pathway does 5-HT3 activation cause nausea and vomiting?
Vagal afferents.
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