5-HT2C partial agonist
5-HT2C serotonin receptor partial agonist
- Intermediate appetite and mood effects
- Less weight gain than full 5-HT2C blockade
- Effect direction depends on ambient serotonin tone
Drugs with this mechanism (5)
- Aripiprazole — D2 partial agonist; weight-favorable, activating, low prolactin; can cause akathisia.
- Aripiprazole lauroxil LAI — Long-acting aripiprazole prodrug injection for schizophrenia; requires a loading strategy.
- Aripiprazole lauroxil LAI — Rapid-start aripiprazole lauroxil injection used only to initiate Aristada treatment.
- Aripiprazole monohydrate LAI — Extended-interval aripiprazole LAI for schizophrenia and bipolar maintenance.
- Aripiprazole monohydrate LAI — Long-acting aripiprazole for schizophrenia and bipolar maintenance; akathisia remains prominent.
Self-check
- How does weight gain with 5-HT2C partial agonism compare with full blockade?
Less weight gain. - What determines the direction of a 5-HT2C partial agonist's effect?
Ambient serotonin tone.
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