Tryptophan
precursor
“L tripped a fan”
What it isEssential amino acid and the precursor of serotonin and melatonin.
Why this oneThe rate-limiting substrate for serotonin synthesis, which is why depletion studies lower mood.
What limits it⚑ Contaminated product caused the 1989 eosinophilia-myalgia epidemic. Serotonin syndrome with serotonergic drugs.
Used for
- dietary supplement / serotonin precursor
- insomnia
- antidepressant augmentation
NO BOXED WARNINGS
Principal risk⚑ Contaminated product caused the 1989 eosinophilia-myalgia epidemic
Classes and tags
Clinical profile
Defining liabilitySerotonergic interactions, drowsiness and hypersensitivity
Available strengths
- cap 500, 1000 mg
Active metabolites
Open Tryptophan in the interactive console ↗
Self-check
- Which two signaling molecules derive from tryptophan?
Serotonin and melatonin. - What caused the 1989 tryptophan-associated eosinophilia-myalgia epidemic?
Contaminated product.