Tazobactam

What it isA penicillanic-acid-sulfone beta-lactamase inhibitor paired with piperacillin (and with ceftolozane).

Why this oneIt extended piperacillin into the workhorse empiric agent for mixed and anaerobic infection.

What limits itIt cannot protect against carbapenemases or AmpC hyperproducers, and the piperacillin combination carries the nephrotoxicity-with-vancomycin association.