Talinolol

What it isTalinolol is a beta-1-selective adrenoceptor antagonist (beta-blocker) that undergoes minimal hepatic metabolism.

Why this oneBecause it is a well-characterized substrate of intestinal and renal P-glycoprotein, it is used chiefly as a clinical probe to study P-gp-mediated drug transport and interactions.

What limits itIt is not approved in the United States, and its disposition is markedly altered by P-glycoprotein inhibitors and inducers such as rifampin and verapamil.