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Simethicone

GAS-X

What it isNonabsorbed silicone antifoaming agent that coalesces gas bubbles; symptomatic bloating and flatulence.

Why this oneBecause it stays in the gut, systemic toxicity and drug interactions are negligible.

What limits itDiscontinue if symptoms do not improve; evidence is weak, and it changes bubble dispersion rather than gas production.

FDA-approved for

FDA label

FDA dosingPopulationStartTargetMax
Gas / bloating reliefAdults1-2 tablets PRN after meals & QHS4 tablets/24 h

Renal Undefined

Hepatic Undefined

Instructions

Pregnancy Undefined

Lactation Undefined

NO BOXED WARNINGS

Principal riskLittle; not absorbed

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Simethicone ballicule

Simethicone ballicule: receptor binding, kinetics and half-life diagram

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