Schisandra
(gomisins)
What it isA medicinal berry (Schisandra chinensis/sphenanthera) used in traditional Chinese medicine as an adaptogen and hepatoprotectant.
Why this oneIts lignans (e.g., schisantherin, deoxyschisandrin) make it one of the more potent botanical modulators of human drug metabolism.
What limits itIt inhibits intestinal and hepatic CYP3A4 and P-glycoprotein, markedly raising exposure to substrates such as tacrolimus, midazolam, and sirolimus.
NO BOXED WARNINGS
Principal riskNo FDA boxed warning.
Classes and tags
Clinical profile
Mechanism of action: Schisandra ballicule
