Withdrawn from the market (safety)
Norfloxacin
NOROXIN
What it isAn older oral fluoroquinolone antibacterial that inhibits bacterial DNA gyrase and topoisomerase IV.
Why this oneHistorically used for uncomplicated urinary tract infections and prostatitis, but it achieves poor systemic and tissue concentrations and has been largely superseded.
What limits itCarries the fluoroquinolone class boxed warnings, may exacerbate myasthenia gravis, and its absorption is markedly reduced by antacids and divalent cations.
⚠ BOXED WARNINGS
- Tendinitis and tendon rupture
- Peripheral neuropathy
- CNS effects
- Exacerbation of myasthenia gravis
Principal riskBoxed warning: disabling and potentially irreversible tendinitis/tendon rupture, peripheral neuropathy, and CNS effects; may exacerbate myasthenia gravis.
Classes and tags
Clinical profile
Mechanism of action: Norfloxacin ballicule
