Nicotinamide
NIACINAMIDE
What it isAmide form of vitamin B3, a NAD precursor; pellagra and skin cancer chemoprophylaxis.
Why this oneUnlike niacin it does not cause flushing, and it reduces non-melanoma skin cancer in high-risk patients.
What limits itIt does not lower lipids, which niacin does — the two are not interchangeable. Hepatotoxicity at very high doses.
FDA-approved for
- pellagra / niacin deficiency
Off-label
- pellagra
- skin cancer chemoprevention
- actinic keratosis
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Dietary supplement | Adult | 1–2 tablets QD | 1–2 tablets QD |
Renal Undefined
Hepatic Undefined
Instructions
- Take 1–2 tablets daily as a dietary supplement, as directed by physician
Pregnancy Undefined
Lactation Undefined
NO BOXED WARNINGS
Principal riskIt has no lipid effect at all, unlike niacin — the two are often confused
Classes and tags
Clinical profile
Active metabolites
Mechanism of action: Nicotinamide ballicule
