Milk
(calcium)
What it isA common dietary beverage rich in calcium and magnesium (divalent cations) plus casein protein.
Why this oneIts divalent cations chelate certain oral drugs in the gut lumen, forming poorly absorbed insoluble complexes that reduce systemic exposure and efficacy.
What limits itMilk substantially lowers absorption of tetracyclines and fluoroquinolones (and can affect bisphosphonates and levothyroxine), so these agents should be separated from dairy by several hours.
NO BOXED WARNINGS
Principal riskNo FDA boxed warning.
Classes and tags
Clinical profile
Mechanism of action: Milk ballicule
