Latanoprost free acid
from latanoprost
What it isFree acid of latanoprost — the active prostaglandin-F2alpha analog after corneal esterases cleave the ester.
Why it mattersThe ester exists to cross the cornea; the acid is what raises uveoscleral outflow and lowers intraocular pressure.
What it changesLocal action and negligible systemic exposure permit once-daily drops with few systemic effects.
NO BOXED WARNINGS
Classes and tags
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Self-check
- Which enzymes activate latanoprost in the cornea?
Corneal esterases. - Why is latanoprost delivered as an ester rather than the active acid?
To cross the cornea.