Guanabenz
WYTENSIN
Pronunciation: GWAHN-a-benz
What it isCentral alpha-2 agonist; hypertension.
Why this oneClonidine-like agent retained where clonidine is not tolerated.
What limits itRebound hypertension on withdrawal, sedation and dry mouth. Now rarely used.
Guanabenz prescription history
Animated chart of estimated U.S. prescriptions per year, Antihypertensives (1953–2026). Guanabenz enters in 1982 (estimated).
FDA-approved for
- hypertension (1982)
NO BOXED WARNINGS
Principal riskRebound hypertension on withdrawal, sedation and dry mouth
Classes and tags
Clinical profile
Legacy pregnancy categoryC
Defining liabilitySedation, bradycardia and rebound hypertension
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Self-check
- What can abrupt guanabenz withdrawal cause?
Rebound hypertension. - Which two common effects limit guanabenz?
Sedation and dry mouth.