GHB (Oxybate)

XYREM

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What it isGABA-B and GHB receptor agonist; narcolepsy with cataplexy, as sodium or mixed-salt oxybate.

Why this oneIt consolidates slow-wave sleep and reduces cataplexy, which stimulants do not treat.

What limits itProfound CNS and respiratory depression requires a REMS; alcohol and sedatives are contraindicated. Abuse in drug-facilitated assault is notorious.

FDA-approved for

narcolepsy (cataplexy/EDS) (2002)

⚠ BOXED WARNINGS

CNS depression
Abuse and misuse

Classes and tags

Neurotransmitters
Sleep medications
Very short half-life drugs

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: GHB (Oxybate) ballicule

GHB (Oxybate) ballicule: receptor binding, kinetics and half-life diagram

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Memory aids: mascots and interaction avatars

GHB (Oxybate) XYREM mascot mnemonic cartoon — **“Skyrim’s Good Hard Beverage (GHB)”**
Dragon from The Elder Scrolls V: Skyrim
approved for narcolepsy with cataplexy
liquid drop on cataplexy sufferer (degeneration of orexin neurons)
cataplexy – falling on the cat under plexiglass
large sodium exposure, more than with XYWAV

no kinetic interactions

Open GHB (Oxybate) in the interactive console ↗