5-HMT
from fesoterodine
What it is5-hydroxymethyl tolterodine, the active metabolite of both fesoterodine and tolterodine; overactive bladder.
Why it mattersTwo marketed drugs converge on this molecule, explaining their similar behavior.
What it changesAnticholinergic burden. Fesoterodine reaches it by esterase hydrolysis, bypassing CYP2D6 variability; tolterodine does not.
NO BOXED WARNINGS
Principal riskAnticholinergic burden
Classes and tags
Open 5-HMT in the interactive console ↗
Self-check
- Which two drugs produce 5-HMT?
Tolterodine and fesoterodine. - Which precursor uses esterases to bypass CYP2D6 formation?
Fesoterodine.