E3
What it isE3 — the weakest of the three classical estrogens, made in quantity by the placenta.
Why it mattersIt is the estrogen of pregnancy: maternal serum estriol reflects fetoplacental function, which gave it a role in antenatal screening.
What it changesIts weak receptor activity outside pregnancy leaves it a minor player pharmacologically in the U.S.
NO BOXED WARNINGS
