Des-ciclesonide
from ciclesonide
What it isThe active metabolite of ciclesonide, formed by esterases in the airway; asthma.
Why it mattersActivation happens IN the lung, so oropharyngeal steroid exposure is minimal and thrush is rare.
What it changesSystemic absorption still occurs at high dose. It is a CYP3A4 substrate.
NO BOXED WARNINGS
Principal riskSystemic absorption at high dose
Classes and tags
Clinical profile
Mechanism of action: Des-ciclesonide ballicule
