Des-ciclesonide
from ciclesonide
What it isActive metabolite of ciclesonide, formed by esterases in the airway; asthma.
Why it mattersActivation happens IN the lung, so oropharyngeal steroid exposure is minimal and thrush is rare.
What it changesSystemic absorption still occurs at high dose. It is a CYP3A4 substrate.
NO BOXED WARNINGS
Principal riskSystemic absorption at high dose
Classes and tags
Open Des-ciclesonide in the interactive console ↗
Self-check
- Where do esterases form des-ciclesonide?
In the airway/lung. - Which enzyme metabolizes des-ciclesonide?
CYP3A4.