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Creatine

Creatine ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Creatine ballicule
Creatine mascot mnemonic cartoon
Visual mnemonic: Creatine mascot
“Creating (muscle)”
Tyler the Creator

What it isNitrogenous acid made from glycine, arginine and methionine that, as phosphocreatine, buffers ATP regeneration in muscle and brain.

Why this oneAmong the best-supported sports supplements for short-burst power output, and it is under study in neurologic and psychiatric conditions where cerebral energetics are implicated.

What limits itRaises serum creatinine — which looks like renal impairment on a basic metabolic panel and is not — and causes weight gain from intracellular water; benefit outside high-intensity exercise is unsettled.

Creatine molecular structure (skeletal formula)
Molecular structure: Creatine

NO BOXED WARNINGS

Classes and tags

Clinical profile

Therapeutic safety burden0 / 4
Weight-gain liability1 / 4
Direct muscarinic antagonism0 / 4

Available strengths

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