Clidinium
in LIBRAX
Pronunciation: kli-DIN-ee-um
What it isQuaternary ammonium antimuscarinic with antispasmodic and antisecretory effects on the gut; in the US it is sold only inside LIBRAX, with chlordiazepoxide.
Why this oneFully ionized, so it is incompletely absorbed and does not readily enter the CNS or the eye: its anticholinergic load is peripheral.
What limits itDry mouth, blurred vision, urinary hesitancy and constipation; contraindicated in glaucoma and in prostatic hypertrophy or bladder-neck obstruction.
FDA-approved for
- GI disorders, adjunct (with chlordiazepoxide, as LIBRAX) (1966)
NO BOXED WARNINGS
Principal riskAnticholinergic effects; contraindicated in glaucoma and prostatic hypertrophy