Cilastatin
in PRIMAXIN
Pronunciation: sye-la-STAT-in
What it isRenal dehydropeptidase inhibitor; never given alone, always with imipenem (PRIMAXIN, and with relebactam in RECARBRIO).
Why this oneLimits renal imipenem metabolism, so imipenem is not given without it.
What limits itNot an antibacterial itself: spectrum, seizure risk and renal dose adjustment all belong to imipenem.
NO BOXED WARNINGS
Classes and tags
Clinical profile
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Self-check
- Which antibiotic must accompany cilastatin?
Imipenem. - Does cilastatin itself provide antibacterial activity?
No.