Celiprolol

What it isA cardioselective beta-1 adrenergic antagonist with partial beta-2 agonist and mild vasodilatory activity.

Why this oneUsed outside the US for hypertension and shown to reduce arterial events in vascular Ehlers-Danlos syndrome.

What limits itA P-glycoprotein and OATP substrate whose absorption is reduced by food and by transporter-modulating drugs.