Benazeprilat
from benazepril
What it isThe active metabolite of benazepril — the diacid that actually inhibits ACE.
Why it mattersHepatic esterases convert the ester prodrug benazepril to this molecule, responsible for essentially all its effect.
What it changesRenal clearance of this metabolite, not the parent, drives accumulation and dose adjustment in kidney disease.
NO BOXED WARNINGS
Classes and tags
Open Benazeprilat in the interactive console ↗
Self-check
- What generates benazeprilat from benazepril?
Hepatic esterases. - Which clearance explains benazeprilat accumulation in kidney disease?
Renal clearance.