DuoDote

What it isAtropine 2.1 mg plus pralidoxime chloride 600 mg in one intramuscular auto-injector (DUODOTE, 2006) — the field antidote for organophosphorus nerve-agent and insecticide poisoning, given by trained emergency personnel as soon as symptoms appear.

Why this oneAtropine blocks the muscarinic flood (secretions, bronchospasm, bradycardia) while pralidoxime reactivates acetylcholinesterase before the enzyme–organophosphate bond ages — the two mechanisms the poisoning needs at once, in one needle.

What limits itThree auto-injectors should be available per patient; it is initial treatment, not a substitute for airway support, decontamination and continued atropinization in hospital.