Apple juice
(OATP inhibitor)
What it isA common fruit juice, not a drug, whose flavonoids inhibit intestinal OATP uptake transporters.
Why this oneUnlike grapefruit juice it does not inhibit CYP3A4, so its interactions arise from reduced drug uptake rather than altered metabolism.
What limits itIt can markedly lower the oral absorption and plasma levels of OATP substrates such as fexofenadine, atenolol, and aliskiren, blunting their effect.
NO BOXED WARNINGS
Principal riskNo FDA boxed warning.
Classes and tags
Clinical profile
Mechanism of action: Apple juice ballicule
