Apple juice
(OATP inhibitor)
What it isCommon fruit juice, not a drug; its flavonoids inhibit intestinal OATP uptake transporters.
Why this oneUnlike grapefruit juice it does not inhibit CYP3A4, so its interactions arise from reduced drug uptake rather than altered metabolism.
What limits itCan markedly lower oral absorption and plasma levels of OATP substrates such as fexofenadine, atenolol, and aliskiren, blunting their effect.
NO BOXED WARNINGS
Principal riskNo FDA boxed warning.
Classes and tags
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Self-check
- Does apple juice inhibit CYP3A4 like grapefruit juice?
No. - How can apple juice affect OATP-substrate absorption?
It can markedly lower it.