α-Tocopherol
VITAMIN E
What it isVitamin E, a lipid-soluble antioxidant; deficiency in fat malabsorption.
Why this oneIt is the specific treatment for the ataxia of vitamin E deficiency, which is otherwise progressive.
What limits itHigh-dose supplementation raises hemorrhagic stroke and all-cause mortality, so it is not a general antioxidant. It potentiates warfarin.
FDA-approved for
- vitamin E deficiency
Off-label
- vitamin E deficiency
- nonalcoholic steatohepatitis
NO BOXED WARNINGS
Principal riskHigh-dose use raises hemorrhagic stroke and mortality
Classes and tags
Clinical profile
Mechanism of action: α-Tocopherol ballicule
