α-Tocopherol
VITAMIN E
What it isVitamin E, a lipid-soluble antioxidant; deficiency in fat malabsorption.
Why this oneSpecific treatment for vitamin E deficiency ataxia, which otherwise progresses.
What limits itHigh-dose supplementation raises hemorrhagic stroke and all-cause mortality, so it is not a general antioxidant. It potentiates warfarin.
Pearls
- 2000 IU/day modestly slowed functional decline in mild–moderate Alzheimer disease.
- Does not prevent dementia.
Used for
- vitamin E deficiency
- nonalcoholic steatohepatitis
NO BOXED WARNINGS
Principal riskHigh-dose use raises hemorrhagic stroke and mortality
Classes and tags
Available strengths
- cap 100, 200, 400, 1000 IU
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Self-check
- What can untreated vitamin E-deficiency ataxia do?
Progress. - Which anticoagulant does alpha-tocopherol potentiate?
Warfarin.