Xanthine oxidase inhibitor
- Inhibits xanthine oxidase metabolism
- Can markedly raise xanthine-oxidase substrates
- Thiopurines are the high-risk classic victims
- Dose reduction/avoidance may be essential
- Allopurinol/febuxostat are prototypes
Interaction at a glance
- Inhibits xanthine oxidase metabolism
Mechanism
- Inhibits xanthine oxidase metabolism
- Can markedly raise xanthine-oxidase substrates
- Allopurinol/febuxostat are prototypes
Clinical consequence
- Thiopurines are the high-risk classic victims
Management
- Dose reduction/avoidance may be essential
Self-check
- Name two xanthine oxidase inhibitors.
Allopurinol and febuxostat. - Which substrates are classic high-risk victims of xanthine oxidase inhibition?
Thiopurines.
Drugs in this interaction (2)
All interaction examples · Open Xanthine oxidase inhibitor in the interactive console ↗