Xanthine oxidase inhibitor
- Inhibits xanthine oxidase metabolism
- Can markedly raise xanthine-oxidase substrates
- Thiopurines are the high-risk classic victims
- Dose reduction/avoidance may be essential
- Allopurinol/febuxostat are prototypes
Interaction at a glance
- Inhibits xanthine oxidase metabolism
Mechanism
- Inhibits xanthine oxidase metabolism
- Can markedly raise xanthine-oxidase substrates
- Allopurinol/febuxostat are prototypes
Clinical consequence
- Thiopurines are the high-risk classic victims
Management
- Dose reduction/avoidance may be essential
Self-check
- Which enzyme or transporter is central to the Xanthine oxidase inhibitor interaction?
xanthine oxidase.
Drugs in this interaction (2)
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