UGT1A1 phenotype-sensitive
- UGT1A1 activity materially affects exposure/toxicity
- Reduced-function alleles impair glucuronidation
- Irinotecan neutropenia is a classic example
- Bilirubin handling also reflects UGT1A1 function
- Genotype-guided dose changes may be appropriate
Interaction at a glance
- UGT1A1 activity materially affects exposure/toxicity
Mechanism
- Irinotecan neutropenia is a classic example
- Bilirubin handling also reflects UGT1A1 function
Clinical consequence
- UGT1A1 activity materially affects exposure/toxicity
Management
- Reduced-function alleles impair glucuronidation
- Genotype-guided dose changes may be appropriate
Self-check
- How do reduced-function UGT1A1 alleles affect metabolism?
Impair glucuronidation. - What toxicity is a classic UGT1A1 example?
Irinotecan neutropenia.
Drugs in this interaction (5)
All interaction examples · Open UGT1A1 phenotype-sensitive in the interactive console ↗