UGT1A1 phenotype-sensitive
- UGT1A1 activity materially affects exposure/toxicity
- Reduced-function alleles impair glucuronidation
- Irinotecan neutropenia is a classic example
- Bilirubin handling also reflects UGT1A1 function
- Genotype-guided dose changes may be appropriate
Interaction at a glance
- UGT1A1 activity materially affects exposure/toxicity
Mechanism
- Irinotecan neutropenia is a classic example
- Bilirubin handling also reflects UGT1A1 function
Clinical consequence
- UGT1A1 activity materially affects exposure/toxicity
Management
- Reduced-function alleles impair glucuronidation
- Genotype-guided dose changes may be appropriate
Self-check
- What is the main clinical risk of UGT1A1 phenotype-sensitive?
UGT1A1 activity materially affects exposure/toxicity.
Drugs in this interaction (5)
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