Seville orange interaction
- Seville orange can inhibit intestinal CYP3A
- Interaction resembles grapefruit for some substrates
- Sweet/common oranges generally do not behave the same
- Exposure can rise for high first-pass CYP3A drugs
- Product type matters
Interaction at a glance
- Seville orange can inhibit intestinal CYP3A
Mechanism
- Seville orange can inhibit intestinal CYP3A
- Interaction resembles grapefruit for some substrates
- Product type matters
Magnitude / time course
- Exposure can rise for high first-pass CYP3A drugs
Mechanism / modifiers
- Sweet/common oranges generally do not behave the same
Self-check
- What does “Seville orange interaction” indicate?
Seville orange can inhibit intestinal CYP3A.
Drugs in this interaction (9)
All interaction examples · Open the interactive console ↗
