Renal clearance (active secretion)
- Kidney actively secretes drug into tubule
- OAT/OCT/MATE transporters commonly participate
- Transporter inhibition can reduce renal clearance
- Creatinine secretion can be altered similarly
- Renal function alone may not predict interaction
Interaction at a glance
- Kidney actively secretes drug into tubule
Mechanism
- Kidney actively secretes drug into tubule
- OAT/OCT/MATE transporters commonly participate
Management
- Transporter inhibition can reduce renal clearance
- Creatinine secretion can be altered similarly
Mechanism / modifiers
- Renal function alone may not predict interaction
Self-check
- What does “Renal clearance (active secretion)” indicate?
Transporter inhibition can reduce renal clearance.
Drugs in this interaction (12)
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