Quetiapine + strong CYP3A inhibitor
- Quetiapine = sensitive CYP3A4 victim
- Strong CYP3A inhibition raises exposure
- Sedation/hypotension toxicity rises
- Label: reduce quetiapine dose to ~1/6
- Reverse adjustment when inhibitor stops
Interaction at a glance
- Strong CYP3A inhibition raises exposure
- Label: reduce quetiapine dose to ~1/6
Mechanism
- Quetiapine = sensitive CYP3A4 victim
- Reverse adjustment when inhibitor stops
Magnitude / time course
- Strong CYP3A inhibition raises exposure
Clinical consequence
- Sedation/hypotension toxicity rises
Management
- Label: reduce quetiapine dose to ~1/6
Self-check
- To what fraction should quetiapine be reduced with a strong CYP3A inhibitor?
About one-sixth.
- About how much can ketoconazole raise quetiapine AUC?
About 6×.
- What toxicity increases with this interaction?
Sedation and hypotension.
Drugs in this interaction (9)
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