Neutropenia/agranulocytosis
- Can markedly reduce neutrophils
- Agranulocytosis = severe infection risk
- Fever/sore throat may require urgent CBC
- Mechanism may be dose-related or idiosyncratic
- Some drugs require scheduled ANC monitoring
Interaction at a glance
- Can markedly reduce neutrophils
Monitoring
- Fever/sore throat may require urgent CBC
Clinical consequence
- Agranulocytosis = severe infection risk
Monitoring / follow-up
- Can markedly reduce neutrophils
- Mechanism may be dose-related or idiosyncratic
- Some drugs require scheduled ANC monitoring
Self-check
- What major clinical effect is associated with Neutropenia/agranulocytosis?
Agranulocytosis = severe infection risk.
Drugs in this interaction (16)
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