Neutropenia/agranulocytosis

Interaction at a glance

• Can markedly reduce neutrophils

Monitoring

• Fever/sore throat may require urgent CBC

Clinical consequence

• Agranulocytosis = severe infection risk

Monitoring / follow-up

• Can markedly reduce neutrophils
• Mechanism may be dose-related or idiosyncratic
• Some drugs require scheduled ANC monitoring

Self-check

• Key clinical effect of Neutropenia/agranulocytosis?
  Agranulocytosis = severe infection risk.
• What symptoms may require urgent CBC when neutropenia is a concern?
  Fever or sore throat.

Drugs in this interaction (16)

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