MATE2-K inhibitor
- Inhibits MATE2-K
- MATE2-K renal exporter
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits MATE2-K
- MATE2-K renal exporter
Mechanism
- Inhibits MATE2-K
- MATE2-K renal exporter
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What transport role and location characterize MATE2-K?
Renal exporter. - What determines an inhibitor’s effect direction for transporter substrates?
Uptake versus efflux location.
Drugs in this interaction (3)
All interaction examples · Open MATE2-K inhibitor in the interactive console ↗