MAO-B substrate
- Metabolized by monoamine oxidase B
- MAO-B inhibition can reduce substrate breakdown
- Brain monoamine handling may be affected
- Clinical importance is substrate-specific
- Other clearance pathways often contribute
Interaction at a glance
- Metabolized by monoamine oxidase B
Management
- Metabolized by monoamine oxidase B
- MAO-B inhibition can reduce substrate breakdown
Mechanism
- Brain monoamine handling may be affected
Magnitude / time course
- Clinical importance is substrate-specific
- Other clearance pathways often contribute
Self-check
- Which enzyme or transporter is central to the MAO-B substrate interaction?
MAO-B.
Drugs in this interaction (2)
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