Lumateperone/lurasidone + strong CYP3A inhibitor
- Both rely heavily on CYP3A4
- Strong inhibitors cause large increases
- lurasidone + ketoconazole AUC ↑ ~9×
- lumateperone + itraconazole ↑ ~3.8×
- Lurasidone: combination contraindicated
- Lumateperone: avoid strong CYP3A blockers
Interaction at a glance
- Strong inhibitors cause large increases
- lurasidone + ketoconazole AUC ↑ ~9×
- lumateperone + itraconazole ↑ ~3.8×
- Lurasidone: combination contraindicated
Management
- Both rely heavily on CYP3A4
- Lurasidone: combination contraindicated
Magnitude / time course
- Strong inhibitors cause large increases
- lurasidone + ketoconazole AUC ↑ ~9×
- lumateperone + itraconazole ↑ ~3.8×
Management / timing
- Lumateperone: avoid strong CYP3A blockers
Self-check
- How are strong CYP3A inhibitors handled with lurasidone vs lumateperone?
Lurasidone: contraindicated; lumateperone: avoid.
- About how much can ketoconazole raise lurasidone AUC?
About 9×.
Drugs in this interaction (10)
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