Ionization (weak acid)
- Acidic drug is more unionized at low pH
- Ionization affects membrane diffusion + renal trapping
- Alkaline urine can increase renal elimination
- Protein binding is often high but not obligatory
- pKa determines the clinically relevant pH range
Interaction at a glance
- Acidic drug is more unionized at low pH
Mechanism
- Acidic drug is more unionized at low pH
Mechanism / modifiers
- Protein binding is often high but not obligatory
- pKa determines the clinically relevant pH range
Mechanism / exceptions
- Ionization affects membrane diffusion + renal trapping
- Alkaline urine can increase renal elimination
Self-check
- What does “Ionization (weak acid)” mean?
Acidic drug is more unionized at low pH.
Drugs in this interaction (5)
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