Distribution (tissue sequestration)
- Drug accumulates in specific tissues
- Tissue stores can prolong half-life/toxicity
- Plasma concentration may underestimate total burden
- Organ-specific toxicity may follow sequestration
- Dialysis often cannot access deep tissue stores
Interaction at a glance
- Drug accumulates in specific tissues
Mechanism
- Plasma concentration may underestimate total burden
- Dialysis often cannot access deep tissue stores
Mechanism / modifiers
- Drug accumulates in specific tissues
Clinical consequence
- Tissue stores can prolong half-life/toxicity
- Organ-specific toxicity may follow sequestration
Self-check
- What is the main clinical risk of Distribution (tissue sequestration)?
Tissue stores can prolong half-life/toxicity.
Drugs in this interaction (8)
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