Dialyzable
- Hemodialysis can meaningfully remove drug/toxin
- Favorable traits: small Vd, low protein binding
- Low molecular size/water solubility also help
- Clinical benefit depends on toxicity + clearance
- Modern high-flux dialysis can change old rules
Interaction at a glance
- Hemodialysis can meaningfully remove drug/toxin
Mechanism
- Favorable traits: small Vd, low protein binding
Mechanism / modifiers
- Low molecular size/water solubility also help
- Modern high-flux dialysis can change old rules
Clinical consequence
- Hemodialysis can meaningfully remove drug/toxin
- Clinical benefit depends on toxicity + clearance
Self-check
- What drug properties favor hemodialysis removal?
Small Vd and low protein binding.
- Does being dialyzable guarantee clinical benefit from dialysis?
No; toxicity and clearance also matter.
Drugs in this interaction (14)
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