CYP3A5 phenotype-sensitive substrate
- CYP3A5 expression materially affects clearance
- Expressers may need higher doses for same exposure
- Tacrolimus is the classic clinical example
- Genotype-guided dosing can improve initial targeting
- CYP3A4 inhibitors still remain important
Interaction at a glance
- CYP3A5 expression materially affects clearance
Magnitude / time course
- CYP3A5 expression materially affects clearance
- Tacrolimus is the classic clinical example
- CYP3A4 inhibitors still remain important
Management
- Expressers may need higher doses for same exposure
Mechanism
- Genotype-guided dosing can improve initial targeting
Self-check
- Which drug is the classic CYP3A5 phenotype-sensitive example?
Tacrolimus. - What dosing difference may CYP3A5 expressers need for the same exposure?
Higher doses.
Drugs in this interaction (6)
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