CYP2C9 inhibitor
- Inhibits CYP2C9
- CYP2C9 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Toxicity risk rises with narrow-index victims
- Inhibition often begins faster than induction
- Warfarin/phenytoin/NSAIDs are classic substrates.
Interaction at a glance
- Inhibits CYP2C9
Magnitude / time course
- Inhibits CYP2C9
- CYP2C9 substrate exposure can rise
Mechanism
- Effect is greatest for sensitive substrates
- Inhibition often begins faster than induction
- Warfarin/phenytoin/NSAIDs are classic substrates.
Clinical consequence
- Toxicity risk rises with narrow-index victims
Self-check
- Key risk with CYP2C9 inhibitor?
Toxicity risk rises with narrow-index victims. - How does the onset of CYP2C9 inhibition often compare with induction?
Inhibition often begins faster.
Drugs in this interaction (3)
All interaction examples · Open CYP2C9 inhibitor in the interactive console ↗