CYP2C9 inducer
- Induces CYP2C9 activity/expression
- CYP2C9 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Warfarin/phenytoin/NSAIDs are classic substrates.
Interaction at a glance
- Induces CYP2C9 activity/expression
Mechanism
- Induces CYP2C9 activity/expression
- CYP2C9 substrates usually clear faster
Mechanism / modifiers
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Warfarin/phenytoin/NSAIDs are classic substrates.
Clinical consequence
- AUC/effect may fall → treatment failure
Self-check
- Which enzyme or transporter is central to the CYP2C9 inducer interaction?
CYP2C9.
- What usually happens to a sensitive CYP2C9 substrate when a CYP2C9 inducer is added?
Its exposure decreases.
Drugs in this interaction (6)
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